Experiences with a new oral mercurial diuretic; merpurate.

OU RAL administration of diuretics with a safe and satisfactory diuresis has always been a therapeutic goal. Diuresis could then be accomplished at a slow but regular rate, with the avoidance of a sudden profuse diuresis,' which is very uncomfortable for the patient, and produces marked alteration of the fluid and electrolyte balance. Rapid diuresis has been known to cause attacks of gout,2 tetany,3 and cerebral thrombosis.4 It has caused the low salt syndrome, and overdigitalization. Hence, slow diuresis is of some importance. Furthermore, oral diuretics avoid the necessity of frequent visits to the doctor and the financial burden thereof. They also eliminate the distasteful injections and allow the patient to handle his own care within safe limits. The general recognition of the need of a safe and good oral diuretic without undesirable side effects is shown by the great number that have appeared upon the therapeutic scene in a relatively short span of time.